Innovations in Chronic Pain Therapeutics
White Mountain Pharma has demonstrated in feasibility studies that its testosterone gel therapy can reduce fatigue in patients with chronic unresolvable fatigue (“Treatment of pain in fibromyalgia patients with testosterone gel: Pharmacokinetics and clinical response”, White, H.D. et al, International Immunopharmacology, 2015). The treatment of fibromyalgia patients with chronic fatigue in this way represents a novel way of thinking about these patients, despite clinical knowledge that testosterone replacement therapy decreases fatigue (Lamberts “Endocrinology and Aging” in Williams Textbook of Endocrinology 12th ed 2011, Chapter 27 pp1219-1233).
The Centers for Disease Control and Prevention offers the following information on Chronic Fatigue Syndrome:
“Chronic fatigue syndrome, or CFS, is a devastating and complex disorder. People with CFS have overwhelming fatigue and a host of other symptoms that are not improved by bed rest and that can get worse after physical activity or mental exertion. They often function at a substantially lower level of activity than they were capable of before they became ill.
Besides severe fatigue, other symptoms include muscle pain, impaired memory or mental concentration, insomnia, and post-exertion malaise lasting more than 24 hours. In some cases, CFS can persist for years.
Researchers have not yet identified what causes CFS, and there are no tests to diagnose CFS. Moreover, because many illnesses have fatigue as a symptom, doctors need to take care to rule out other conditions, which may be treatable.
There are several case definitions for CFS and all require fatigue as one of the symptoms. CDC uses the 1994 CFS case definition, which requires meeting three criteria:
These symptoms should have persisted or recurred during 6 or more consecutive months of illness, and they cannot have first appeared before the fatigue.”
MedlinePlus: Chronic Fatigue Syndrome